Cancer survivors will be recognized and lead in a victory walk around the track.
There will be food booths, silent auctions, games for the children, entertainment and more throughout the night.
The Relay event winds down several months of work by teams and committee members to raise funds to fight cancer.
Chairman Brenda Matheny expressed her appreciation to all of the sponsors and workers who give their time and donations to make the event successful each year.
The 2012 theme has a carnival theme, "Walking the Midway for a Cure, One Step at a Time."
Matheny encourages everyone to come out to the Leachville Park on Friday to show support for area cancer survivors and to remember those who have lost their battle to the disease.